Project Information

Reference Number 19940029
Project Title Production, Purification and Immunogenicity of a Malaria Transmission-Blocking Vaccine Candidate: TBV25H expressed in Saccharomyces cerevisiae
Project Type Contained Use (Laboratory)
Status N/A
Name of Institution National Institute of Molecular Biology and Biotechnology (BIOTECH),University of the Philippines Los Banos, College, Laguna,049-536-2721; 536-2724
Cooperating Institution National Institutes of Health
Supervising IBC UPLB-IBC
Project Leader(s) Fidel Rey P. Nayve
Experimental Facility/Site Philippines (Biotech- UPLB)
Purpose / Objectives 1. To establish yeast fermentation, protein purification and vaccine formulation capabilities for producing research- grade recombinant subunit vaccines in the Philippines.
2. To establish procedures for manufacturing yeast- derived recombinant subunit vaccines under Good Manufacturing Guidelines in the Philippines.
3. To produce a malaria transmission- blocking vaccine suitable for use in human clinical trials in the Philippines.
Biosafety measures All persons involved in the experiment will be oriented on the proper handling and decontamination procedure that will be enforced and BL1 and BL1-LS level containment will be observed.
Conditions for Approval N/A
Date Received 1994-07-18
Date of Approval 1994-07-25


Regulated Materials

Regulated Materials -plasmid: pTBV25HU and yeast: 2905/6 strain
Source N/A
Subject Request of Fidel Rey P. Nayve Jr for permit to import plasmid: pTBV25HU and yeast: 2905/6 strain
Requesting Party Dr. Francisco Zapata, Tissue Culture Specialist
Action of NCBP Approved for implementation

For issuance of permit to import plasmid: pTBV25HU and yeast: 2905/6 strain by the Plant Quarantine Services, Bureau of Plant Industry